Ngohlalutyo lwe-HPLC, ubungakanani bentshuntshelwano yepakethi ye-chromatographic incinci kwaye kulula ukuba ithintelwe ngamasuntswana amdaka. Ke ngoko, iisampulu kunye nezinyibilikisi kufuneka zifakwe kwangaphambili ukususa uluhlu olungcoliseko kwaye lukhusele isixhobo. I-ion chromatography, esetyenziswayo kuhlalutyo lokusingqongileyo, likwafuna ukuba akukho ngcoliseko ye-inrganic ingeniswe kwisampulu yophando. Iifiliti zesirinji zingasetyenziswa kuhlalutyo lwe-HPLC kunye nohlalutyo lwe-ICPROS lokutshintsha izisombululo, eli linyathelo elibalulekileyo kwinkqubo yokutshintsha kwesampulu.