Kuchokera mu madzi acidic mwamphamvu kupita ku Lipophilic mankhwala a Lipophilic, kusankha njira yolakwika yomwe imatha kubwezeretsanso kapena kuyambitsa nsonga za phantom. Bukuli lagawika malire a maofesi a soda-laime vs.

Zofunikira zanu & Zofunikira

Kulimbikira	Chitsanzo wamba	Cholinga chachikulu
Kwamanga zachilengedwe	Madzi otayika (ph 1-3)	Kukana kuwononga; zero chitsulo chachitsulo
Pharma r & d	Apis adasungunuka mu acetonitrile	Zosungunuka-zosungunulira; Adsorption yotsika
Kuyesa Chakudya	Mapulasitiki mu masamba mafuta	Lipophilic Kugwirizana; Chitetezo Chopepuka

Kuyerekeza Zinthu

Malaya	Makhalidwe Abwino	Mankhwala ogwirizana	Mtengo (€ pa vial)	Gwiritsani ntchito milandu
Magalasi a Liime	Okwera mtengo	PH 6-8 kokha	~0.5	Kuphunzitsa ma lab; Madzi ofupika
Otsika-borosil	Zoyambira acid (PH ≥)	Osati HF- kapena Fiel-Officer	★★☆☆☆	Madzi a RPLC HPLC
Pakatikati-Borosil	PH 0.5-10; Ochenjera pa 120 ° C	PH pH; kutentha-osakhazikika	★★★☆☆	PERRMA QC; zitsanzo za bio
Kuchuluka-borosil	PH 0-14; khola lokhazikika	Ma Acids onse \ / zigawo; 500 ° C wokhoza	★★★★☆	Tsatirani \ / acid Acid Acid

Chidziwitso: Makanema apakatikati amakumana ndi USP \ / Magalasi agalasi agalasi. Borosil-borosilther cte ≈3.3 × 10⁻⁶ \ / k vs. 9 × 10 \ / k magalasi wamba.

Kusankha SePA yoyenera

Mtundu wa septum	Kubowola Moyo	Mankhwala ogwirizana	Lepa	Zabwino
PTFF \ / Silicone Corsuteite	15-20 Piercactions	Acids, zodetsa, zolimbitsa thupi	DMF imatha kuthira	HPLC Autosambir imayenda
PTF PTF	Gwiritsani ntchito kamodzi	Onse okhazikika	Kusindikiza Kosauka	GC-MS adalemba mawu
Silicone yowonongeka	30+ PierCings	Acids Ofowoka \ / Zida (PH 3-10)	Imatupa mu acetone	Zosasinthika

Vial & Septa Malangizo pa zitsanzo

Mtundu wa zitsanzo	Analimbikitsa vial	Septum kusankha	Kupita Kupewa
Madzi otayika (PH 1.5)	Vial-borositial momveka bwino	White Ptfe \ / Sicone Corsute	Osagwiritsa ntchito sodi-laimu (imasungunuka mu 24 h)
Zosakhutiritsa mankhwala ku Acetunitrile	Vial-Borosil-Borosil	Blue Ptfe	Operewera otsika kumabweretsa chikondwerero cha peak
Mafuta a masamba a masamba	Amber wamkulu-borosil	Silicone yowonongeka	Galasi yowoneka bwino imafunikira chitetezo chopepuka
Kuphunzitsa Buffer (Osalowerera)	Soda-Liggal Vial	Silika wamba	Kokha kwa nthawi yochepa, osalowerera ndale

Phunziro la milandu: Njira yosamukira mu pharma

Kukhazikitsa Koyambirira:
- Sampy: API mu 0.1% formic acid \ / acetonitrile (1: 1)
- Chidebe: ndulu yotsika kwambiri siyicone septum
Nkhani:
- Nsonga zosadziwika zimawonekera pa jakisoni # 3 (Sicnone Divits)
- Zidziwitso za API zimaponyedwa ndi 12% pambuyo pa 72 h (Glass Adsorption)
Yankho:
- Sinthani ku ma hydrolytic galasi Mbale
- Sinthani mpaka pakhungu lamphamvu
Zotsatira zake:
- Phantom Peaks imachotsedwa
- Kuyeserera kokhazikika <0.8%

Makandulo Ofunika

Ma acid acids → Borotil
Kutsatira kwa Pharma Kutsatira → Pakatikati
Zitsanzo zazifupi kwambiri → Soda-laimu
Chepta Chemistry> Kubowoza Moyo

Maumboni a Data:

USP <660> Chingwe chagalasi
Malipoti otsimikizika a Cma

Ndi chitsogozo ichi, Gwirizanitsani vial yanu ndi septum to protem-pewani kuchuluka kwa ndalama ndikuwonetsetsa zoberekera zoberekera kuwunika zachilengedwe.

M'mbuyomu:

Kodi pali kusiyana kotani pakati pa gc-ms ndi gc-ms \ / ms?

Ena:

Kubwerera pamndandanda

Ma tag: Mbale za HPLC Gc-ms sampu Mbale zapamwamba kwambiri Mbale zapakatikati pagalasi PTFF \ / Silicone septa

Kufunsa