HPLC vs. LC-MS/MS: Cost, Sensitivity and Certified Consumable Requirements
HPLC and LC-MS both separate compounds by liquid chromatography, but they identify what comes off the column in completely different ways. One detects by light absorption, the other by molecular mass. This guide breaks down five critical factors: sensitivity thresholds, selectivity, sample preparation requirements, cost, and consumable specifications. It also explains why most LC-MS problems trace back to low-quality vials and filters, and why certified Type 5.0 vials and 0.22um syringe filters are essential for trace analysis. Free sample kit available.