Ukusuka kumanzi aqatha e-acidic kwiziyobisi ze-lipophilic, ukukhetha isampulu yesampulu ye-vial kungafunwa kwakhona okanye ukuphelisa i-pigger phantom. Esi sikhokelo sigqwetha imida yentsebenzo ye-SODA-I-SODAILICATER GULAS kwaye ibonelele ngezicwangciso ze-vial-and-septha ze-vial-neptas ze-septa ukuya kwi-Spining Grace Stures kwi-Assine Species-Ukuphelisa ukusebenzela i-mismatches.

Isampulu yakho kunye neemfuno zesicelo

Ishishini	Isampulu yesiqhelo	Iimfuno eziphambili zeZitya
Okusingqongileyo	Amanzi amdaka e-acidic (PH 1-3)	Ukunganyangeki; I-Lero Gath Leach
Pharma r & d	I-APIS ichithwe kwi-acetostitrile	Ukunganyangeki kwendalo; i-adsorption ephantsi
Uvavanyo lokutya	Iiplasitifers kwioyile yemifuno	I-Lipophilic uthenge; ukhuseleko lokukhanya

Ukuthelekiswa kwentsebenzo yezinto ezibonakalayo

Isixhobo	Iimpawu eziphambili	Ukuhambelana kwamachili	Iindleko (€ nganye kwi-vial)	Sebenzisa amatyala
Iglasi yesoda-lime	Ixabiso elincinci	pH 6-8 kuphela	~0.5	Iilebhu zokufundisa; Amanzi exesha elifutshane
I-borosililicicate ephantsi	Isiseko esisisiseko sokungakhathali (PH ≥4)	Hayi i-HF-okanye i-on enganyangekiyo	★★☆☆☆	Iindlela ze-phulc zamanzi
I-odumoilicicate	ph 0.5-10; I-Autoclavable kwi-120 ° C	I-PH PH; Ishushu	★★★☆☆	Pharma qc; Iisampulu ze-Bio
I-high-borosilicate	Eyona nto iphambili p0-14; ngokuzinzileyo	Zonke ii-Acids \ / iziseko; I-500 ° C ekwaziyo	★★★★☆	Trace \ / i-harsh-acid hlaluts

Qaphela: I-Opdium-Borosililicicate ihlangabezana ne-USP \ / ye-EP ebuyekayo yeglasi. I-CTE-Cote-Borosililicate CTE ≈3.3 × 10⁻⁶ \ / k vs. 9 × 10⁻⁶ \ / k kwiglasi eqhelekileyo.

Ukukhetha i-septa elungileyo

Uhlobo lweSeptum	Ukubhoboza Ubomi	Ukuhambelana kwamachili	Buyisela	Ilungele
I-ptfe \ / i-silicone portposite	I-15 ukuya kwi-20 ukubhoboza	I-AIDD, iziseko, izinyibilikisiweyo eziphakathi	I-DMF inokulibazisa	I-HPPC AutoMampler isebenza
I-ptfe	Ukusetyenziswa kancinci	Zonke izinyibilikisi eziphilayo	Ukutywinwa kakubi	I-GC-MS Harddied Assoed
Phinda wafumana i-silicone	30+ Hiercings	I-acid ebuthathaka \ / iziseko (PH 3-10)	Shushu kwi-acetone	Izikrini eziphezulu

Iingcebiso ze-Vial & Septa ngesampula

Uhlobo lwesampulu	I-vial enconywayo	Ukhetho lweSeptum	Umngxunya ukuphepha
Amanzi amdaka omzi-mveliso (ph 1.5)	I-vial-borosilicicate vial vial	Mhlophe ptfe \ / i-silicone portposite	Ungaze usebenzise i-soda-lime (inyibilike kwi-24 h)
Ukungcola kweziyobisi kwi-Acetostitrile	I-vial-borosililicicate vial	Iblue ebomvu ye-ptfe	I-borosililicate esezantsi ikhokelela ekutsaleni
Ioyile yemifuno	I-Amber ephezulu-Borosililicate	Phinda wafumana i-silicone	Iglasi ecacileyo ifuna ukhuseleko lokukhanya
Ukufundisa ii-buffers (ukungathathi hlangothi)	I-soda-lime glass vial	I-Silicone esemgangathweni	Kuphela kwiisampulu zexesha elifutshane, ezingathathi hlangothi

Isifundo setyala: Indlela yokudlulisela ukusilela kwi-pharma

Iseti yoqobo:
- Isampuli: API kwi-0.1% fomuc acid \ / Acetotitrile (1: 1)
- Ikhontelo: i-vial-borosililicicate vial + ye-silicone esezantsi ye-septum
Imiba:
- Iincopho ezingaziwayo zivele kwinaliti # 3 (i-silicone ye-leageed)
- Umxholo we-API wehliswa nge-12% emva kwe-72 h (i-adsorve yeglasi)
Isisombululo:
- Phucula kwi-borosililicicate ye-vials ye-hydrolytic
- Tshintshela kwi-PtFE \ ptfe \ / I-Silicone ye-septa (i-Pre-Poierce 5 ×)
Iziphumo:
- I-phantom piks isuse
- Uvavanyo loVavanyo lwe-0.8%

Iqhosha lezitshixo

I-harsh acid → i-surosililicilate ye-right
Ukuthobela i-Pharma
Iisampulu ezingathathi cala zexesha elifutshane → iSoda-Lime
I-Septa Chemistry> Ukubhoboza Ubomi

Izalathiso zedatha:

I-USP <660> Uvavanyo lwe-Inforlig yeGlass
Ingxelo ye-CMA-Eqinisekisiweyo

Ngesi sikhokelo, utshatisa i-vial yakho ye-vial kunye ne-septum kwi chemistry-uphephe ukubuyisela ixabiso kwakhona kwaye kuqinisekiswe iziphumo zokubuyiselwa kuhlalutyo lwendalo esingqongileyo kunye nohlalutyo lwamayeza.

Ngaphambili:

Nguwuphi umahluko phakathi kwe-GC-NS kunye ne-GC-Nks \ / Nks?

Okulandelayo:

Buyela kuLuhlu

Iimpawu: I-HPLC Vials I-GC-MS isampulu ye-PREPE I-vials ephezulu ye-borossilicate I-vials ephakathi ye-borosililicate Ptfe \ / isilicone Septa

Umbuzo