Umugqa wokukhiqiza izidakamizwa we-anticancer wezilwane wase-Europe waseYurophu we-Anticancetical Comment wahlangabezana nazo ezihlangene ne-Anomalies ye-HPLC yokuthola, eneziqongo eziphikelelayo zokuphazanyiswa ezilandela isihloko esikhulu. Uphenyo lwelebhu lulandele umthombo wokungcola kuma-Chromatographic vial faning systems. Iqembu lezobuchwepheshe lika-Aijiren likhombise impande ebangela okutholakele okulandelayo:

Amasiginesha wokungcola anamandla
I-Ghost Peaks ekhonjiswe isikhathi sokugcina sokugcina

Ukuxhumeka Kwezinto Ezibonakalayo
Ukutholwa okuhlanganisiwe kwe-LC-MS kuvezwe izingcezwana ezingokomfanekiso ze-PTFE (C8F16, m \ z 412.96) Eziqongweni ezingaziwa, ukuhambelana kwamakhemikhali amakhemikhali).

I-Core Mechanism
I-torque elwamanje engajwayelekile yabangela ukulimala okungahambisane ne-septum, ekhiqiza izinhlayiya ezingama-50-200μm ezifake amakholomu we-chromatographic ngokugeleza kwesigaba seselula ngokugeleza kwesigaba seselula.

II. Ukuqinisekiswa kwe-Experimental: Ukuphumelela ekuhlolweni kwe-torque-decformation-conformation

I-AIJIREN yasungulwa ubufakazi obuphelele phakathi kweTorque-HPLC ehlanganisiwe:

Ukumbumbuluzwa kwe-torque gradient
Izilungiselelo ezintathu ze-torque (eziphansi \ medium \ aphezulu
I-SEM iqinisekisiwe: I-Over-Torque (> 2.5NM) inqoba ukugxila kwengcindezelo, ngenkathi under-torque (<1.0nm) isheshise ukukhala kwezinhlayiyana.

Ukulandelela Ukulandelela Kwe-Dranemics
I-Laser Particle Analyzer ebhekwe ukugxilwa kwe-real-time yesikhathi esigabeni eselula kuwo wonke amasampula alinganiselwe e-torque.
Kuthuthukiswe imodeli ye-3D yokuxhumanisa i-torque, ivolumu yokukhishwa kwezinhlayiyana, kanye ne-ghost peak yendawo yokwenza lula ukukhiqiza.

III. Izixazululo ze-AIJREN: Ukuhlanganiswa kokujula kwezobuchwepheshe nokuqaliswa kwezimboni

Njengomholi wembulunga yonke ekudleni kwe-laboratory, i-AIJIREN yakha amaketanga aphelele okuvimbela ngokuqanjwa kwezinto ezibonakalayo, ukukhiqizwa kwengqondo ukukhiqiza, kanye nezinhlelo zenkonzo:

Izinto ezibonakalayo & zenqubo

Ubuchwepheshe be-composite setum
Ukulawulwa kwe-torque ehlakaniphile: I-algorithms eguquguqukayo ye-vial diemeter enamamojula wokunxeshezela lokushisa (± 0.05NM ukunemba).

Matrix womkhiqizo ogcwele

Izimali ze-Chromatography: Ama-vials we-Auto-Sampler, amasistimu wokubopha uphawu oluningi, amamojula we-gradient fieltration (UHPLC \ I-HPLC ukuhambisana).

Amathuluzi Wokuhlaziywa Kwamanzi

Inethiwekhi yesevisi ye-Agile Global

Ukulethwa kwe-Global-amahora angama-48 ngemigqa engu-6 ezenzakalelayo (amayunithi angama-500k \ Day, chears 100k Cleans Cleanrooms)
Izixazululo Zokwezifiso: Ukufakwa kwe-Micro-Ukufakwa, izimbotshana ezingamelana ne-HF-amelana, ama-simulators aguqukayo ashukumisayo.

IV. Inani lamakhasimende: kusuka ekuxazululeni izinkinga ukuze uvikeleke ekuvikeleni ubungozi

Kungani aijiren?

Ukusebenza kwezindleko:Ukwehliswa kwezindleko ezingama-30% ngokusebenza okuqondayo okulinganiselwe kokuphathwa kanye nokuphathwa okulengayo.
Ukuncipha kobungozi:Ukulethwa kwe-zero-decect nge-blockchain-enikwe amandla umlandeli (i-FDA 21 CFR ingxenye 11 ukuthobela).
Ubuholi bobuchwepheshe:Izixazululo ezihlanganisiwe zeTorque-HPLC zihlanganisa ukungcoliswa okunamandla kanye nokusebenza kahle kwekholomu ukubola.

Okwedlule:

Igayidi ebalulekile ku-1ml Shell Vavials

Olandelayo:

Ukuhlolwa kwe-Bonded Septa-Off-Off

Amathegi: Ukulawulwa kokungcola okunamandla Ukuxhumeka kweTorque-Deformation Ukuwohloka kwe-PTFE Ukubekwa uphawu kwe-zero-decect Ikhemisi QC

Ukubuza

Isixazululo esiphelele sokungcola okunamandla kwe-HPLC: Ukusuka ekuhlulekeni kwe-torque ku-3-Laler composite

I.Ukuhlaziywa Kwembangela Yezimpande: Osekufihliwe Kokungcola Okunamandla

​​II. Ukuqinisekiswa kwe-Experimental: Ukuphumelela ekuhlolweni kwe-torque-decformation-conformation

​​III. Izixazululo ze-AIJREN: Ukuhlanganiswa kokujula kwezobuchwepheshe nokuqaliswa kwezimboni