Mass S.

Bongata ba linaleli bo eme pele ho nahanisisa ka mahlale, le tlhahlobo ea eona e ikhethang ba e etsa sesebelisoa sa bohlokoa sa ho khetholla le ho eketsa limolek'hule. Mokhoa o sebetsang ka ho fetola sampole ka lithibela le ho lekanya likarolo tse ngata tsa tefo (M \ Z), e lumella bafuputsi ba khethollang meaho ea lisele. MS e bapala karolo ea bohlokoa-motheong ea liprothemo, metabolomics, nts'etsopele ea lithethefatsi, ho beha sethethefatsi. Maeto a eona a ho fana ka tlhaiso-leseling e qaqileng ea lisele e ntse e tsoela pele ho khanna se okamiloeng litaelong tsa saense tse fapaneng.

Melao-motheo ea Matšoele a Manohana

Mass S. Ka MS, mohlala, mohlala, mohlala, mohlala, mohlala, mohlala, mohlala o qotsitsoeng o aroloa ebile o lekantsoe ho latela liteishene tsa bona tsa ho sokola. Tekanyetso e tloaelehileng ea pono e na le likarolo tse tharo tsa mantlha:

• Mohloli oa ION: E hlahisa li-ion tsa moea tse tsoang ho limolek'hule tsa mohlala.

• Mohlahlobi oa Machaba: E rarolla lihlekehleke ka literene tsa bona tsa ho beha ka bongata.
  

  

• Seteishene: E hlahella lihlekehleke tse arohaneng 'me li lekanya metso ea tsona.

Ts'ebetso ea tlhahlobo e ama mehato e mengata:

1. Tlhahiso ea Ion: Mohlala o isoa ho hlahisa li-ions tsa lisele tse koahetsoeng (hangata ka mekhoa e kang ea Electric Ionizations.

2. Ion Paintion: Ions ha e hloekisoe kapa e arotsoe ho ea ka M \ Z ho ea sekaseka.

3. Liroto tsa ion (Haeba ho hlokahala) Lihlekehleke tse Khethiloeng li ka senyeha ka seleng e kenang ho senola tlhaiso-leseling.

4. Ho lemoha le ho rekota: Liteko tsa ho qetela tsa Ions tsa ho qetela le ho tlaleha Spectrim Setsebi sena se fana ka boima ba limolek'hule le lintlha tsa sebopeho sa bahlahlobi.
   
   

   U batla ho tseba hore na GC handpace ke eng?Tobetsa mona ho tseba haholoanyane

Ho hloka tsebo ka har'a sizemrometry

Mekhoa ea ionization

Lipolelo tsa ionization li na le bokhoni bo eketsehileng ba MS. Mohlala, ionization ea electrossspping (ESI) e bone litlhahiso tse kholo; Nano-electroray (Nano-esi) o sebelisa capillaries e ntle haholo ho hlahisa marotholi a qotsitsoeng ka tsela e nyane haholo, ka ho etsa joalo. Ho Matrix-Oponthud Laser Desoordown \ Ionization (Maldi), Metsoako e Meholo ea Metsoako ea Li-Iota Mekhoa ea ho imeloa ke Ionization e joalo ka ho lahla Ionization (dessi) le tlhahlobo e tobileng. Mekhoa ena e etsa tlhahlobo e potlakileng, ea sebakeng sa marang-rang bakeng sa lits'ebeliso tse phahameng tsa lits'ebeletso tsa tikoloho le taolo ea tikoloho.

Sekaseka theknoloji

Lipolelo tsa lihlahla tse boima li ntlafalitse haholo. Mohlala, mohlahlobi oa lihlahla o fana ka qeto ea Ultaigh, ba ntse ba eketseha tšimong ea elektrome moo ho hlahisa litekanyo tse matla haholo. Lisebelisoa tsa sejoale-joale tsa sejoale-joale li ka fihlela liqeto tsa bongata ka holimo ho 100,000 tsa boleng bo bolelele m \ Lenaneo la lintho tsa Ion cyclotron la ion cyclotron (ft Ho bonts'a Tof (Mong-Tof) o phahamisa tsela ea sefofane ho ea maemong a mangata, qeto e 'ngoe ea ho holisa sesebelisoa. Litsamaiso tsa Hybrid li kopanya mahlale: quadrupole-ortinse le liletsa tsa quadrule ho fihlela lebelo le lebelo le phahameng. Lintho tsena tse nyalisitsoeng li fana ka tebeletso le ho nepahala ha tlhahlobo e rarahaneng ea sampole. Ntle le moo, tšilafalo ea li-qqq) Qqq e sebelisoa haholo ka bongata bo boholong le ba fanang ka litekanyetso tsa tšebeliso e tšepahalang ea boitšoaro bo tšepahalang.

Ts'ebetso ea data le ai

Tsoelo-pele ea Harddedted, mekhoa ea software le ea tlhaiso-leseling e feto-fetohang ka potlako. Ho ithuta mochini (ML) le bohlale ba maiketsetso Mekhoa ena e ka fumana litlhōrō tsa pono, matšoao a fetang a desconvoluving, 'me a khethoa ho sekaseka ka nepo, ho fokotsa phoso ea motho. Mohlala, li-algorith tse tsoetseng pele li ka supa le ho khetholla litlhoro, li lokisa lerata la motheo le ho fana ka liphetho tse hlakileng. Mefuta e joalo e tsamaisang liphallelo le ho ntlafatsa tlhahiso, e leng ho nyatsa lithuto tse ngata tsa prosepeotic le metabolomic.

Likopo tsa Lihlopha Tse Bongata

Mafura a mangata a sebetsa masimong a mangata a fapaneng, ho kenyelletsa:

• Lithepumpikis le Metabolomics: Litoneng tsa Bophelo, MS e thusa ho fumana liprotheine le ho khetholla lipelaelo tsa li-sampole tse thata, li sibolla lits'oants'o tsa biomarker le metabolical tsela ea metaboliker. Bafuputsi ba ka utloisisa limolek'hule tsa cellular tsa cellular ho utloisisa lits'ebetso tsa likoetliso le mekhoa ea mafu.

• Lits'oants'o tsa bongaka le biomedicine:Ka bongaka, MS e sebelisoa ho khetholla baetso ba mefuta, ho ithuta litlhao tsa lithethefatsi, le ts'ehetso ea ts'ehetso ea ts'ehetso. Mohlala, protheine kapa boikhaoloti ba metabolite ka har'a mali kapa lisele li ka hlahlojoa ho fumana mafu a pele kapa a lekola karabelo ea kalafo ea pele.

• Ho lekola tikoloho le li-fornistric:MS detects pollutants in air, water, and soil (such as heavy metals, pesticides, and organic toxins) and identifies toxins and drugs in biological samples, ensuring environmental and public safety. Ka mohlala, ho hlahloba tlhahlobo ea metsi bakeng sa masala a thibelo ea meriana kapa moea oa moea oa khale bakeng sa mekhatlo e sa tloaelehang ho ka fihlelloa ka kutloisiso e phahameng.

• Polokeho ea lijo le lisebelisoa tsa thepa:MS e sebelisoa ho leka bakeng sa litlokotseba le litlatsetso lijong le lino tse entsoeng ka masala, li-adstive tse seng molaong), ho netefatsa polokeho ea sehlahisoa. Hape ke ea bohlokoa hape ka thepa ea mahlale le nanotechnology bakeng sa ho tšoaea sebopeho sa lik'hemik'hale le sebopeho sa lisebelisoa tse ncha.

• Pherekano ea Tlhahlobo le Tlhahlobo e le 'ngoe ea sele:Liletsa tse sekasekang tsa MS sekaseka li-samomprest tsa ho leboha (e.
  

  

Bokamoso bo Haufi

E le tsoelo-pele ea theknoloji, litloaelo tse ncha li ntse li hlaha ka har'a lipolanete tse kholo. Mohlala, ho ikopanya ha mehloli ea Microfluid, mehloli ea Novel Nanowe e sirel e le 'ngoe ea data e ntlafalitsoeng Ka kakaretso, masene a mangata a tla tsoela pele ho sutumelletsa meeli ea saense libakeng tse kang ho beha leihlo tikoloho, bongaka le k'hemistri tsa mantlha.