Maximize Efficiency with High-Recovery HPLC Vials
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High-recovery HPLC vials

Jun. 14th, 2024
During HPLC sample testing, we'll encounter tests that need a small sample. Usually, these samples are more valuable. So, it's crucial to protect their integrity, recovery rate, and stability. Ordinary sample vials are not good for trace testing. They can cause sample loss and contamination. They can also contaminate precious samples and reduce test accuracy. The laboratory selects the sample vials for trace testing. They are often vials with fixed inner tubes or vials with inner tubes. But, their recovery rate is not ideal for precious samples. Is there a vial that has a high rate of recovery? You will, of course, be introduced to "high recovery sample vials" in this essay.

What is high-recovery HPLC vials?

High recovery sample vials (also called high recovery HPLC sample vials)


Transparent and brown high-recovery sample containers are available. They are made of high-quality borosilicate. Brown high-recovery vials can filter out some ultraviolet and visible light. They are used to protect samples from light.

Bottle mouth

The bottle mouth of high-recovery sample vials has two main types. These are threaded and crimp mouths.

Screw-neck vials provide reliable sealing. They are good for long-term storage or samples with high sealing needs. However, it's necessary to rotate the screw cap to open and close it. Improper operation may touch the sample, making contamination more likely.

Crimp-neck vials don't need to be rotated. They just need to be closed with tools. This reduces the risk of sample contamination. At the same time, the metal crimp cap has magnetic attraction. However, crimp-neck vials need a special capping device. This is more cumbersome to use than screw-neck vials.

Curious about chromatography vial caps? Read this article to learn more: How to Choose the Right Type of Closure for Your Chromatography Vials


High recovery sample vials look like ordinary sample vials. However, the bottom of high recovery sample vials is V-shaped. This shape reduces sample residue and adhesion to improve sample recovery. The fine design is the key to its ultra-high recovery. It also makes residue small, sampling easy, and contamination low.

Usages of high-recovery HPLC vials

High-recovery sample vials are great for small samples. However, they will not combine standard 2mL sample vials with separate vial inserts. You can use high-recovery sample vials for sample concentration and injection. You don't need to transfer the sample to a micro-insert. The vials ensure that the needle draws as much sample as possible. They ensure that as much precious sample is drawn as possible. They apply to HPLC and GC instruments. The instruments are used in many fields. These fields need micro sample preparation and analysis. These fields include drugs, the environment, energy, fuels, forensics, and materials. They also include biotech drugs, proteomics, and metabolomics.


In the early stages of drug development, we determine the drug's active ingredients. We also determine its efficacy and safety. Sample vials with high recovery can keep the sample safe. This keeps the analysis accurate and repeatable.

Drug quality control, drug stability research, and biological sample storage can all use vials. The recovery of the vials is high. The accuracy and recovery of sample test results have improved.

Want to learn more about how chromatography vials are used in environmental monitoring? You can read this article: Exploring the Environmental Monitoring Applications of Chromatography Vials (6 Mainly Applications)


Vials for high-recovery samples are very useful in environmental monitoring. They can be used to keep an eye on contaminants, microbes, and nutrients in water when monitoring water quality.

In atmospheric monitoring, they can be used to collect air samples for the analysis of various gases and particulate matter. In soil monitoring, they are used to collect soil samples for the analysis of various pollutants and nutrients. In biological monitoring, it's used to collect biological samples. These are used to analyze biological parameters and environmental impacts.

Energy and fuels

In energy and fuels, people use high-recovery sample vials. They use them for fuel quality control. They also use them for fuel property research, fuel additive research, and for energy storage and conversion analysis.

Forensic medicine

In forensic medicine, high-recovery sample vials are mainly used. They're for collecting corpse tissue and body fluids. They're used in toxicology, DNA, and trace analysis.

How do chromatography vials specifically play a role in forensic science? You will find the answer here: Forensic Science Applications of Chromatography Vials

Materials Science

The vials are also applicable to the field of materials science. Using high-recovery sample vials is great for sample prep and storage. They are also great for material performance testing and analysis. Additionally, they are also great for material synthesis and modification.


In biopharmaceuticals, vials with high recovery can speed up cell and medium recovery. They are for storing, preparing, and filling biological samples and preparations. They are also for monitoring bioreactors.

Proteomics and metabolomics

In the field of proteomics and metabolomics, it can be used for sample collection and pretreatment, protein analysis, metabolite analysis, data collection and analysis.

To explore more about Chromatography Vials for Proteomics and Genomics Research, click here to get started: Chromatography Vials for Proteomics and Genomics Research

The standard use of high-recovery sample vials can achieve a sample recovery rate of 99%, which is an ideal choice for high-value sample testing!